Structural proteomics: high-throughput methods

Structural proteomics: the potential of high-throughput structure determination.

The pharmaceutical industry has embraced genomics as a means to identify new biological targets for target-based drug discovery approaches. Now, genomics is driving a substantial effort in protein structure determination and structure prediction. These structures will provide the opportunity to undertake structure-guided drug discovery programs in the search for new classes of broad-spectrum an...

Structural proteomics: prospects for high throughput sample preparation.

Structural proteomics: prospects for high throughput sample preparation Dinesh Christendat, Adelinda Yee, Akil Dharamsia,y, Yuval Kluger, Mark Gerstein, Cheryl H. Arrowsmith*, Aled M. Edwards Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G2M9 C.H. Best Institute, Banting and Best Department of Medical Rese...

Native mass spectrometry: towards high-throughput structural proteomics.

Native mass spectrometry (MS) has become a sensitive method for structural proteomics, allowing practitioners to gain insight into protein self-assembly, including stoichiometry and three-dimensional architecture, as well as complementary thermodynamic and kinetic aspects. Although MS is typically performed in vacuum, a body of literature has described how native solution-state structure is lar...

A streamlined approach to high-throughput proteomics.

Proteomics has rapidly become an important tool for life science research, allowing the integrated analysis of global protein expression from a single experiment. To accommodate the complexity and dynamic nature of any proteome, researchers must use a combination of disparate protein biochemistry techniques, often a highly involved and time-consuming process. Whilst highly sophisticated, indivi...

High-throughput Image Analysis for Proteomics